Endocrine Abstracts

Introduction: Homocysteine is an intermediate sulfur amino acid in the metabolic pathways of cysteine production from methionine, which is increasingly involved in various pathological processes (arterial thrombosis, depression, schizophrenia, dementia). We are interested in the course of our work to study the variation of homocysteine levels in diabetic subjects with venous thrombosis.Materials and methods: This is an observational case-control study, c...

Introduction: Homocysteine is an intermediate sulfur amino acid in the metabolic pathways of cysteine production from methionine, which is increasingly involved in various pathological processes (arterial thrombosis, depression, schizophrenia, dementia). We are interested in the course of our work to study its implication on the lipid balance in patients with venous thrombosis.Materials and methods: This is an observational case-control study, comparing ...

Introduction: Cortisone-induced osteoporosis (CO) is the most frequent complication of corticosteroid therapy. It is the first cause of secondary osteoporosis. The aim of this study is to clarify the characteristics of CO.Patients and Methods: We report a retrospective study of 39 cases of CO among 128 cases of osteoporosis during a 15-year period. The diagnosis of CO was based on a bone densitometry (BMD) of more than -1.5 standard deviations.<p cla...

Introduction: Osteoporosis is a generalized skeletal disease that combines a decrease in bone density with changes in bone microarchitecture. The bone is abnormally fragile and therefore the risk of fracture is high. We report the case of osteoporosis in a young woman secondary to type 1 diabetes mellitus (T1DM).Case Report: Patient A.M, 26 years old, with a history of polyglandular autoimmune syndrome type 3 since the age of 12, associating T1DM and Has...

Introduction: The aim of this study was to investigate the characteristics of glucocorticoid-induced diabetes (GCID) in 18 non-diabetic patients before the initiation of corticosteroid therapy.Patients and Methods: It is a retrospective study including non-diabetic hospitalized patients who developed diabetes after initiation of corticosteroid therapy.Results: Eighteen patients (5 males/13 females) with a mean age of 59.5 years wer...

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Hashimoto’s encephalopathy (HE) is characterised by the combination of clinical signs of encephalitis and autoimmune thyroiditis with elevated levels of antithyroid antibodies (ATA). It is a rare condition and its etiopathogenesis is still poorly understood.Observation: we present a 33-year-old female patient who was hospitalized for gait disorders. The diagnosis of a chronic cerebellar syndrome related to Hashimoto’s encephalitis...

Introduction: Hypothyroidism is a consequence of thyroid hormone deficiency which may be of peripheral or central origin. If hypothyroidism is left untreated, the symptoms progress and lead to life-threatening complications.Patients and method: Retrospective study of 67 patients with primary hypothyroidism. We determined the different complications associated with hypothyroidism.Results: We collected 67 patients with overt hypothyr...